MolNFT v1 · #120550 · protein
Apo form of GEMIN5-wd
5H3S · Gem-associated protein 5: “Apo form of GEMIN5-wd”. X-ray diffraction, 15 pockets (best druggability 0.80). MolNFT v1 #120550 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5H3S
- Type
- protein
- Length
- 1,300 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gem-associated protein 5
- UniProt
- Q8TEQ6
- Pockets
- 15 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gem-associated protein 5 | protein | 655 | 3% helix, 48% strand | Q8TEQ6 |
| B | Gem-associated protein 5 | protein | 645 | 3% helix, 47% strand | Q8TEQ6 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1003 | 0.80 | 0.81 | 63 | empty |
| 2 | 1017 | 0.79 | 0.81 | 66 | empty |
| 3 | 507 | 0.76 | 0.84 | 48 | empty |
| 4 | 444 | 0.74 | 0.83 | 42 | empty |
| 5 | 72 | 0.57 | 0.88 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 163 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 covalent (additive adduct).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TEQ6
- Elsewhere: RCSB PDB 5H3S · PDBe 5H3S · UniProt Q8TEQ6
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