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MolNFT v1 · #120542 · protein

Crystal structure of grasp domain of GRASP55 complexed with the GOLGIN45 C-terminus

5H3J · Golgi reassembly-stacking protein 2: “Crystal structure of grasp domain of GRASP55 complexed with the GOLGIN45 C-terminus”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.46). MolNFT v1 #120542 on GenesisL1: 3D…

PDB
5H3J
Type
protein
Length
218 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Golgi reassembly-stacking protein 2; Golgin-45
UniProt
Q99JX3, Q8R2X8
Ligands
ZN
Pockets
1 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 13% helix, 32% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AGolgi reassembly-stacking protein 2protein19714% helix, 34% strandQ99JX3
BGolgin-45protein210% helix, 14% strandQ8R2X8

Ligands and binding sites

  • ZN · Zinc ion · metal · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11060.460.8023empty

Interfaces

1 interface between chains.

  • A–B · 1279 Ų buried · 22 hydrogen bonds · protein-protein

Compared structures

  • 5H3J · Crystal structure of Grasp domain of Grasp55 complexed with the Golgin45 C-terminus · the same entry in another collection · chain A against A, TM-score 1.00
  • Q99JX3 · AlphaFold monomer V2.0 prediction for golgi reassembly-stacking protein 2 (Q99JX3) · a predicted model of the same protein · chain A against A, TM-score 0.75
  • Q8R2X8 · AlphaFold monomer V2.0 prediction for golgin-45 (Q8R2X8) · a predicted model of the same protein · chain B against A, TM-score 0.27

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