MolNFT v1 · #120542 · protein
Crystal structure of grasp domain of GRASP55 complexed with the GOLGIN45 C-terminus
5H3J · Golgi reassembly-stacking protein 2: “Crystal structure of grasp domain of GRASP55 complexed with the GOLGIN45 C-terminus”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.46). MolNFT v1 #120542 on GenesisL1: 3D…
- PDB
- 5H3J
- Type
- protein
- Length
- 218 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Golgi reassembly-stacking protein 2; Golgin-45
- UniProt
- Q99JX3, Q8R2X8
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Golgi reassembly-stacking protein 2 | protein | 197 | 14% helix, 34% strand | Q99JX3 |
| B | Golgin-45 | protein | 21 | 0% helix, 14% strand | Q8R2X8 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.46 | 0.80 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1279 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 5H3J · Crystal structure of Grasp domain of Grasp55 complexed with the Golgin45 C-terminus · the same entry in another collection · chain A against A, TM-score 1.00
- Q99JX3 · AlphaFold monomer V2.0 prediction for golgi reassembly-stacking protein 2 (Q99JX3) · a predicted model of the same protein · chain A against A, TM-score 0.75
- Q8R2X8 · AlphaFold monomer V2.0 prediction for golgin-45 (Q8R2X8) · a predicted model of the same protein · chain B against A, TM-score 0.27
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99JX3
- Every structure of UniProt Q8R2X8
- Elsewhere: RCSB PDB 5H3J · PDBe 5H3J · UniProt Q99JX3 · UniProt Q8R2X8
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