MolNFT v1 · #120439 · protein

Name to be released when published

5H0I · Asparaginyl endopeptidase: “Name to be released when published”. X-ray diffraction, 9 pockets (best druggability 0.51). MolNFT v1 #120439 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5H0I
Type: protein
Length: 800 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Asparaginyl endopeptidase
EC: 3.4.22.34
UniProt: A0A0N9JZ32
Pockets: 9 · best druggability 0.51

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Asparaginyl endopeptidase (EC 3.4.22.34)	protein	400	44% helix, 13% strand	A0A0N9JZ32
B	Asparaginyl endopeptidase (EC 3.4.22.34)	protein	400	43% helix, 13% strand	A0A0N9JZ32

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	163	0.51	0.79	34	empty
2	172	0.50	0.78	31	empty
3	144	0.47	0.77	34	empty
4	67	0.44	0.82	22	empty
5	93	0.32	0.73	20	empty

Interfaces

1 interface between chains.

A–B · 737 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5H0I · Structure of OaAEP1 asparaginyl peptide ligase in its proenzyme form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0N9JZ32
Elsewhere: RCSB PDB 5H0I · PDBe 5H0I · UniProt A0A0N9JZ32

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.