MolNFT v1 · #120304 · protein

Structural insight into dephosphorylation by trehalose 6-phosphate phosphatase (OTSB2) from mycobacterium tuberculosis

5GVX · Trehalose-phosphate phosphatase: “Structural insight into dephosphorylation by trehalose 6-phosphate phosphatase (OTSB2) from mycobacterium…”. X-ray diffraction, 1 ligand (MG), 1 pocket (best druggability 0.71). MolNFT v1 #120304 on…

PDB: 5GVX
Type: protein
Length: 386 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trehalose-phosphate phosphatase
EC: 3.1.3.12
UniProt: P9WFZ5
Ligands: MG
Pockets: 1 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Trehalose-phosphate phosphatase (EC 3.1.3.12)	protein	386	34% helix, 24% strand	P9WFZ5

Ligands and binding sites

MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1133	0.71	0.75	84	MG

Compared structures

5GVX · Structural insight into dephosphorylation by Trehalose 6-phosphate Phosphatase (OtsB2)… · the same entry in another collection · chain A against A, TM-score 1.00
P9WFZ5 · AlphaFold monomer V2.0 prediction for trehalose-phosphate phosphatase (P9WFZ5) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WFZ5
Elsewhere: RCSB PDB 5GVX · PDBe 5GVX · UniProt P9WFZ5

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