MolNFT v1 · #120279 · protein

Y74COX mutant of plasmodium falciparum triosephosphate isomerase

5GV4: “Y74COX mutant of plasmodium falciparum triosephosphate isomerase”. X-ray diffraction, 1 ligand (PGA), 1 pocket (best druggability 0.37). MolNFT v1 #120279 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5GV4
Type: protein
Length: 245 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Triosephosphate isomerase
EC: 5.3.1.1
UniProt: Q07412
Ligands: PGA
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Triosephosphate isomerase (EC 5.3.1.1)	protein	245	43% helix, 16% strand	Q07412

Ligands and binding sites

PGA · 2-phosphoglycolic acid · ligand · chains A
EDO · 1,2-ethanediol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	95	0.37	0.75	16	empty

Compared structures

5GV4 · Y74COX mutant of plasmodium falciparum triosephosphate isomerase · the same entry in another collection · chain A against A, TM-score 1.00
Q07412 · AlphaFold monomer V2.0 prediction for triosephosphate isomerase (Q07412) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07412
Elsewhere: RCSB PDB 5GV4 · PDBe 5GV4 · UniProt Q07412

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.