MolNFT v1 · #120185 · protein
Full-length NS1 structure of zika virus from 2015 brazil strain
5GS6 · NS1 of zika virus from 2015 brazil strain: “Full-length NS1 structure of zika virus from 2015 brazil strain”. X-ray diffraction, 1 ligand (NAG), 8 pockets (best druggability 0.79). MolNFT v1 #120185 on GenesisL1: 3D structure…
- PDB
- 5GS6
- Type
- protein
- Length
- 701 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NS1 of zika virus from 2015 brazil strain
- Ligands
- NAG
- Pockets
- 8 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NS1 of zika virus from 2015 brazil strain | protein | 352 | 14% helix, 31% strand | — |
| B | NS1 of zika virus from 2015 brazil strain | protein | 349 | 15% helix, 30% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.79 | 0.98 | 24 | empty |
| 2 | 373 | 0.78 | 0.88 | 46 | empty |
| 3 | 184 | 0.70 | 0.88 | 33 | empty |
| 4 | 423 | 0.67 | 0.79 | 53 | empty |
| 5 | 54 | 0.48 | 0.86 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2351 Ų buried · 54 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 5GS6 · Full-length NS1 structure of Zika virus from 2015 Brazil strain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5GS6 · PDBe 5GS6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.