MolNFT v1 · #120174 · protein

Crystal structure of homo-specific diabody

5GRV · Homo-specific diabody heavy chain: “Crystal structure of homo-specific diabody”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #120174 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5GRV
Type: protein
Length: 229 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Homo-specific diabody heavy chain; Homo-specific diabody light chain
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Homo-specific diabody heavy chain	protein	123	12% helix, 50% strand	—
K	Homo-specific diabody light chain	protein	106	6% helix, 46% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.46	0.81	20	empty
2	80	0.32	0.74	17	empty

Interfaces

1 interface between chains.

L–K · 722 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

5GRV · Crystal structure of homo-specific diabody · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5GRV · PDBe 5GRV

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