MolNFT v1 · #12009 · protein

Crystal structure of the methyltransferase with a knot from methanobacterium thermoautotrophicum

1K3R · Conserved protein MT0001: “Crystal structure of the methyltransferase with a knot from methanobacterium thermoautotrophicum”. X-ray diffraction, 5 pockets (best druggability 0.71). MolNFT v1 #12009 on GenesisL1: 3D structure…

PDB: 1K3R
Type: protein
Length: 526 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Conserved protein MT0001
UniProt: O26109
Pockets: 5 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Conserved protein MT0001	protein	262	29% helix, 24% strand	O26109
B	Conserved protein MT0001	protein	264	28% helix, 23% strand	O26109

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.71	0.94	23	empty
2	51	0.70	0.98	13	empty
3	106	0.62	0.88	24	empty
4	145	0.40	0.74	22	empty
5	141	0.38	0.73	25	empty

Interfaces

1 interface between chains.

A–B · 1885 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

1K3R · Crystal Structure of the Methyltransferase with a Knot from Methanobacterium… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O26109
Elsewhere: RCSB PDB 1K3R · PDBe 1K3R · UniProt O26109

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