MolNFT v1 · #119979 · protein

Human endothelin receptor type-B in the ligand-free form

5GLI · Endothelin receptor subtype-B: “Human endothelin receptor type-B in the ligand-free form”. X-ray diffraction, 2 ligands (OLA, SO4), 6 pockets (best druggability 0.78). MolNFT v1 #119979 on GenesisL1: 3D structure, binding sites and…

PDB: 5GLI
Type: protein
Length: 429 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endothelin receptor subtype-B
Ligands: OLA, SO4
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 78% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Endothelin receptor subtype-B	protein	429	78% helix, 4% strand	—

Ligands and binding sites

OLA · Oleic acid · ligand · chains A
SO4 · Sulfate ion · ion · 5 copies · chains A
OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1072	0.78	0.79	71	empty
2	212	0.62	0.82	32	SO4
3	121	0.40	0.75	19	empty
4	75	0.40	0.78	14	SO4
5	63	0.32	0.76	15	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

5GLI · Human endothelin receptor type-B in the ligand-free form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5GLI · PDBe 5GLI

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