MolNFT v1 · #119971 · protein

Crystal structure of the class a beta-lactamase penl-TTR10 containing 10 residues insertion in omega-loop

5GLA: “Crystal structure of the class a beta-lactamase penl-TTR10 containing 10 residues insertion in omega-loop”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #119971 on GenesisL1: 3D structure, binding sites and…

PDB: 5GLA
Type: protein
Length: 533 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactamase
EC: 3.5.2.6
UniProt: A0A2Z4SUB5
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-lactamase (EC 3.5.2.6)	protein	267	43% helix, 21% strand	A0A2Z4SUB5
B	Beta-lactamase (EC 3.5.2.6)	protein	266	42% helix, 20% strand	A0A2Z4SUB5

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1013	0.74	0.77	98	empty
2	67	0.43	0.81	21	empty
3	117	0.41	0.76	20	empty
4	71	0.31	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 563 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5GLA · Crystal structure of the class A beta-lactamase PenL-tTR10 containing 10 residues… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A2Z4SUB5
Elsewhere: RCSB PDB 5GLA · PDBe 5GLA · UniProt A0A2Z4SUB5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.