MolNFT v1 · #119966 · protein
Sterol 3-beta-glucosyltransferase (UGT51) from saccharomyces cerevisiae (strain atcc 204508 / S288C): udpg complex
5GL5: “Sterol 3-beta-glucosyltransferase (UGT51) from saccharomyces cerevisiae (strain atcc 204508 / S288C): udpg…”. X-ray diffraction, 1 ligand (UPG), 10 pockets (best druggability 0.78). MolNFT v1 #119966 on GenesisL1: 3D structure…
- PDB
- 5GL5
- Type
- protein
- Length
- 862 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sterol 3-beta-glucosyltransferase
- EC
- 2.4.1.173
- UniProt
- Q06321
- Ligands
- UPG
- Pockets
- 10 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sterol 3-beta-glucosyltransferase (EC 2.4.1.173) | protein | 431 | 50% helix, 14% strand | Q06321 |
| B | Sterol 3-beta-glucosyltransferase (EC 2.4.1.173) | protein | 431 | 51% helix, 13% strand | Q06321 |
Ligands and binding sites
- UPG · Uridine-5'-diphosphate-glucose · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 278 | 0.78 | 0.90 | 49 | empty |
| 2 | 251 | 0.74 | 0.88 | 39 | UPG |
| 3 | 182 | 0.73 | 0.90 | 33 | UPG |
| 4 | 207 | 0.68 | 0.85 | 31 | empty |
| 5 | 119 | 0.67 | 0.88 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1518 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 5GL5 · Sterol 3-beta-glucosyltransferase (ugt51) from Saccharomyces cerevisiae (strain ATCC… · the same entry in another collection · chain A against A, TM-score 1.00
- Q06321 · AlphaFold monomer V2.0 prediction for sterol 3-beta- glucosyltransferase (Q06321) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06321
- Elsewhere: RCSB PDB 5GL5 · PDBe 5GL5 · UniProt Q06321
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