MolNFT v1 · #119911 · protein
Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 2
5GJD · TAK1 kinase - TAB1 chimera fusion protein: “Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 2”. X-ray diffraction, 1 ligand (6V3), 2 pockets (best druggability 0.71). MolNFT v1 #119911 on GenesisL1: 3D…
- PDB
- 5GJD
- Type
- protein
- Length
- 292 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TAK1 kinase - TAB1 chimera fusion protein
- EC
- 2.7.11.25
- UniProt
- O43318, Q15750
- Ligands
- 6V3
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TAK1 kinase - TAB1 chimera fusion protein (EC 2.7.11.25) | protein | 292 | 39% helix, 16% strand | O43318, Q15750 |
Ligands and binding sites
- 6V3 · 1-(4-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-3-(5-(4-methylpiperazin-1-yl)naphthalen-2-yl)urea · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 331 | 0.71 | 0.84 | 40 | 6V3 |
| 2 | 70 | 0.32 | 0.74 | 22 | empty |
Compared structures
- 5GJD · Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 2 · the same entry in another collection · chain A against A, TM-score 1.00
- O43318 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase kinase kinase 7… · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q15750 · AlphaFold monomer V2.0 prediction for TGF-beta-activated kinase 1 and MAP3K7-binding… · a predicted model of the same protein · chain A against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43318
- Every structure of UniProt Q15750
- Elsewhere: RCSB PDB 5GJD · PDBe 5GJD · UniProt O43318 · UniProt Q15750
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