MolNFT v1 · #119700 · protein
Structure of gc glycoprotein from severe fever with thrombocytopenia syndrome virus in the trimeric postfusion conformation
5G47 · Sftsv gc: “Structure of gc glycoprotein from severe fever with thrombocytopenia syndrome virus in the trimeric…”. X-ray diffraction, 2 ligands (NAG, CL), 19 pockets (best druggability 0.84). MolNFT v1 #119700 on GenesisL1: 3D…
- PDB
- 5G47
- Type
- protein
- Length
- 1,284 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sftsv gc
- UniProt
- R4V2Q5
- Ligands
- NAG, CL
- Pockets
- 19 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Sftsv gc | protein | 428 | 6% helix, 54% strand | R4V2Q5 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A, B, C
- CL · Chloride ion · ion · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 817 | 0.84 | 0.86 | 89 | empty |
| 2 | 358 | 0.82 | 0.91 | 61 | empty |
| 3 | 141 | 0.81 | 0.98 | 26 | empty |
| 4 | 503 | 0.80 | 0.87 | 68 | empty |
| 5 | 501 | 0.79 | 0.86 | 64 | empty |
Interfaces
3 interfaces between chains.
- B–C · 2609 Ų buried · 32 hydrogen bonds · protein-protein
- A–C · 2600 Ų buried · 40 hydrogen bonds · protein-protein
- A–B · 2516 Ų buried · 39 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 39 disulfide, 3 glycan (disulfide, N-glycosylation).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt R4V2Q5
- Elsewhere: RCSB PDB 5G47 · PDBe 5G47 · UniProt R4V2Q5
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