MolNFT v1 · #119659 · protein

Crystallographic structure of mutant W31A of thioredoxin from litopenaeus vannamei

5G2Z: “Crystallographic structure of mutant W31A of thioredoxin from litopenaeus vannamei”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #119659 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5G2Z
Type: protein
Length: 210 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thioredoxin
EC: 1.8.1.9
UniProt: B1PWB9
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Thioredoxin (EC 1.8.1.9)	protein	105	41% helix, 26% strand	B1PWB9

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.42	0.77	25	empty
2	85	0.34	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 348 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

5G2Z · Crystallographic structure of mutant W31A of thioredoxin from Litopenaeus vannamei · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B1PWB9
Elsewhere: RCSB PDB 5G2Z · PDBe 5G2Z · UniProt B1PWB9

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