MolNFT v1 · #119405 · protein

Pig liver esterase 5 (PLE5)

5FV4 · Carboxylic ester hydrolase: “Pig liver esterase 5 (PLE5)”. X-ray diffraction, 20 pockets (best druggability 0.76). MolNFT v1 #119405 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5FV4
Type: protein
Length: 3,180 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carboxylic ester hydrolase
EC: 3.1.1.1
UniProt: A9GYW6
Pockets: 20 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Carboxylic ester hydrolase (EC 3.1.1.1)	protein	530	39% helix, 17% strand	A9GYW6

Pockets

20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	793	0.76	0.80	83	empty
2	751	0.74	0.79	81	empty
3	373	0.72	0.83	53	empty
4	58	0.71	0.97	24	empty
5	874	0.69	0.75	66	empty

Interfaces

10 interfaces between chains.

A–D · 539 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 446 Å² buried · 0 hydrogen bonds · protein-protein
A–E · 386 Å² buried · 3 hydrogen bonds · protein-protein
A–B · 340 Å² buried · 2 hydrogen bonds · protein-protein
A–F · 328 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

5FV4 · Pig liver esterase 5 (PLE5) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9GYW6
Elsewhere: RCSB PDB 5FV4 · PDBe 5FV4 · UniProt A9GYW6

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