MolNFT v1 · #119315 · protein
Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation and a template for drug design
5FSG · Maltose-binding periplasmic protein, hantavirus…: “Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation and a…”. X-ray diffraction, 1 ligand (GLC), 6 pockets (best druggability 0.73).…
- PDB
- 5FSG
- Type
- protein
- Length
- 661 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic protein, hantavirus nucleoprotein
- UniProt
- P0AEX9, P05133
- Ligands
- GLC
- Pockets
- 6 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic protein, hantavirus nucleoprotein | protein | 661 | 48% helix, 12% strand | P0AEX9, P05133 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 453 | 0.73 | 0.83 | 36 | GLC |
| 2 | 115 | 0.47 | 0.79 | 21 | empty |
| 3 | 115 | 0.40 | 0.75 | 18 | empty |
| 4 | 61 | 0.40 | 0.80 | 14 | empty |
| 5 | 98 | 0.40 | 0.76 | 19 | empty |
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
- 5FSG · Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt P05133
- Elsewhere: RCSB PDB 5FSG · PDBe 5FSG · UniProt P0AEX9 · UniProt P05133
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