MolNFT v1 · #119297 · protein

Crystal structure of the phenol-responsive sensory domain of the transcription activator poxr

5FRU · Positive phenol-degradative gene regulator: “Crystal structure of the phenol-responsive sensory domain of the transcription activator poxr”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.43). MolNFT v1 #119297 on…

PDB: 5FRU
Type: protein
Length: 390 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Positive phenol-degradative gene regulator
UniProt: O84957
Ligands: ZN
Pockets: 3 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Positive phenol-degradative gene regulator	protein	195	50% helix, 25% strand	O84957

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.43	0.81	17	empty
2	92	0.36	0.75	22	empty
3	88	0.33	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 2242 Å² buried · 38 hydrogen bonds · protein-protein

Compared structures

5FRU · crystal structure of the phenol-responsive sensory domain of the transcription activator… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O84957
Elsewhere: RCSB PDB 5FRU · PDBe 5FRU · UniProt O84957

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.