MolNFT v1 · #119296 · protein

Structure of the fesii (shethna) protein of azotobacter vinelandii

5FRT · Dimeric (2FE-2S) protein: “Structure of the fesii (shethna) protein of azotobacter vinelandii”. X-ray diffraction, 1 ligand (FES), 4 pockets (best druggability 0.71). MolNFT v1 #119296 on GenesisL1: 3D structure, binding sites and…

PDB: 5FRT
Type: protein
Length: 581 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dimeric (2FE-2S) protein
UniProt: Q44501
Ligands: FES
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Dimeric (2FE-2S) protein	protein	119	22% helix, 24% strand	Q44501
E	Dimeric (2FE-2S) protein	protein	105	18% helix, 28% strand	Q44501

Ligands and binding sites

FES · Fe2/s2 (inorganic) cluster · ligand · 5 copies · chains A, B, C, D, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	623	0.71	0.79	79	empty
2	264	0.68	0.84	32	empty
3	232	0.66	0.84	33	empty
4	64	0.37	0.78	15	empty

Interfaces

7 interfaces between chains.

A–B · 1259 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 1059 Å² buried · 12 hydrogen bonds · protein-protein
B–E · 366 Å² buried · 3 hydrogen bonds · protein-protein
D–E · 276 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 136 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

5FRT · Structure of the FeSII (shethna) protein of Azotobacter vinelandii · the same entry in another collection · chain E against E, TM-score 1.00
Q44501 · AlphaFold monomer V2.0 prediction for protein fesii (Q44501) · a predicted model of the same protein · chain E against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q44501
Elsewhere: RCSB PDB 5FRT · PDBe 5FRT · UniProt Q44501

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.