MolNFT v1 · #119294 · protein
Structure of the PDS5-SCC1 complex and implications for cohesin function
5FRR · Sister chromatid cohesion protein PDS5: “Structure of the PDS5-SCC1 complex and implications for cohesin function”. X-ray diffraction, 12 pockets (best druggability 0.82). MolNFT v1 #119294 on GenesisL1: 3D structure, binding sites…
- PDB
- 5FRR
- Type
- protein
- Length
- 1,337 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sister chromatid cohesion protein PDS5
- UniProt
- Q04264
- Pockets
- 12 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sister chromatid cohesion protein PDS5 | protein | 677 | 63% helix, 0% strand | Q04264 |
| B | Sister chromatid cohesion protein PDS5 | protein | 660 | 67% helix, 0% strand | Q04264 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1190 | 0.82 | 0.83 | 114 | empty |
| 2 | 52 | 0.69 | 0.96 | 19 | empty |
| 3 | 96 | 0.58 | 0.86 | 24 | empty |
| 4 | 54 | 0.53 | 0.87 | 17 | empty |
| 5 | 89 | 0.49 | 0.82 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 654 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5FRR · Structure of the Pds5-Scc1 complex and implications for cohesin function · the same entry in another collection · chain A against A, TM-score 1.00
- Q04264 · AlphaFold monomer V2.0 prediction for sister chromatid cohesion protein PDS5 (Q04264) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04264
- Elsewhere: RCSB PDB 5FRR · PDBe 5FRR · UniProt Q04264
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