MolNFT v1 · #119191 · protein

Crystal structure of the cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post- transfer editing analogue of isoeucine (ILE2AA)

5FOL: “Crystal structure of the cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a…”. X-ray diffraction, 2 ligands (SO8, PO4), 1 pocket (best druggability 0.74). MolNFT v1 #119191 on GenesisL1: 3D…

PDB: 5FOL
Type: protein
Length: 274 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Leucyl-tRNA synthetase
EC: 6.1.1.4
UniProt: B6AA20
Ligands: SO8, PO4
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leucyl-tRNA synthetase (EC 6.1.1.4)	protein	274	34% helix, 26% strand	B6AA20

Ligands and binding sites

SO8 · 2'-(L-isoleucyl)amino-2'-deoxyadenosine · ligand · chains A
PO4 · Phosphate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	366	0.74	0.85	35	PO4, SO8

Compared structures

5FOL · Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B6AA20
Elsewhere: RCSB PDB 5FOL · PDBe 5FOL · UniProt B6AA20

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