MolNFT v1 · #119174 · protein

Zapc cell division regulator from E. COLI

5FO3 · Cell division protein zapc: “Zapc cell division regulator from E. COLI”. X-ray diffraction, 3 pockets (best druggability 0.65). MolNFT v1 #119174 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5FO3
Type: protein
Length: 336 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division protein zapc
UniProt: P75862
Pockets: 3 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Cell division protein zapc	protein	168	21% helix, 32% strand	P75862

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.65	0.87	24	empty
2	146	0.48	0.78	27	empty
3	58	0.45	0.83	11	empty

Interfaces

1 interface between chains.

A–B · 767 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 20 modified (engineered).

Compared structures

5FO3 · ZapC cell division regulator from E. coli · the same entry in another collection · chain A against A, TM-score 1.00
P75862 · AlphaFold monomer V2.0 prediction for cell division protein zapc (P75862) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P75862
Elsewhere: RCSB PDB 5FO3 · PDBe 5FO3 · UniProt P75862

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