MolNFT v1 · #119130 · protein
MMIFT52 N-terminal domain
5FMS · Intraflagellar transport protein 52 homolog: “MMIFT52 N-terminal domain”. X-ray diffraction, 9 pockets (best druggability 0.73). MolNFT v1 #119130 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5FMS
- Type
- protein
- Length
- 661 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Intraflagellar transport protein 52 homolog
- UniProt
- Q62559
- Pockets
- 9 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 23% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Intraflagellar transport protein 52 homolog | protein | 228 | 22% helix, 25% strand | Q62559 |
| B | Intraflagellar transport protein 52 homolog | protein | 225 | 24% helix, 24% strand | Q62559 |
| C | Intraflagellar transport protein 52 homolog | protein | 208 | 22% helix, 23% strand | Q62559 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 255 | 0.73 | 0.87 | 40 | empty |
| 2 | 101 | 0.69 | 0.91 | 22 | empty |
| 3 | 142 | 0.64 | 0.86 | 26 | empty |
| 4 | 52 | 0.57 | 0.90 | 16 | empty |
| 5 | 216 | 0.54 | 0.78 | 26 | empty |
Interfaces
2 interfaces between chains.
- A–B · 520 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 492 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62559
- Elsewhere: RCSB PDB 5FMS · PDBe 5FMS · UniProt Q62559
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