MolNFT v1 · #119122 · protein
BCL-xl with bak BH3 complex
5FMK: “BCL-xl with bak BH3 complex”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #119122 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5FMK
- Type
- protein
- Length
- 171 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BCL-xl; BCL-2 homologous ANTAGONIST/KILLER
- UniProt
- Q07817, Q16611
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BCL-xl | protein | 150 | 81% helix, 0% strand | Q07817 |
| B | BCL-2 homologous ANTAGONIST/KILLER | protein | 21 | 76% helix, 0% strand | Q16611 |
Ligands and binding sites
- GOL · Glycerol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 88 | 0.33 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1163 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 5FMK · Bcl-xL with Bak BH3 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.76
- Q16611 · AlphaFold monomer V2.0 prediction for BCL-2 homologous ANTAGONIST/KILLER (Q16611) · a predicted model of the same protein · chain B against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07817
- Every structure of UniProt Q16611
- Elsewhere: RCSB PDB 5FMK · PDBe 5FMK · UniProt Q07817 · UniProt Q16611
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.