MolNFT v1 · #119099 · protein

Crystal structure of putative exo-beta-1,3-galactanase from bifidobacterium bifidum S17

5FLW: “Crystal structure of putative exo-beta-1,3-galactanase from bifidobacterium bifidum S17”. X-ray diffraction, 5 pockets (best druggability 0.68). MolNFT v1 #119099 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5FLW
Type: protein
Length: 604 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Exo-beta-1,3-galactanase
EC: 3.2.1.145
UniProt: E4VCC5
Pockets: 5 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Exo-beta-1,3-galactanase (EC 3.2.1.145)	protein	302	2% helix, 45% strand	E4VCC5

Ligands and binding sites

BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	202	0.68	0.86	32	empty
2	203	0.68	0.86	33	empty
3	219	0.60	0.81	28	empty
4	161	0.58	0.82	19	BTB
5	52	0.25	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 979 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

5FLW · Crystal structure of putative exo-beta-1,3-galactanase from Bifidobacterium bifidum s17 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E4VCC5
Elsewhere: RCSB PDB 5FLW · PDBe 5FLW · UniProt E4VCC5

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