MolNFT v1 · #119071 · protein

Structure of E.COLI constitutive lysine decarboxylase

5FKZ · Lysine decarboxylase, constitutive: “Structure of E.COLI constitutive lysine decarboxylase”. Electron microscopy, 8 pockets (best druggability 0.83). MolNFT v1 #119071 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5FKZ
Type: protein
Length: 710 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lysine decarboxylase, constitutive
EC: 4.1.1.18
UniProt: P52095
Pockets: 8 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Lysine decarboxylase, constitutive (EC 4.1.1.18)	protein	710	43% helix, 16% strand	P52095

Pockets

8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1081	0.83	0.84	141	empty
2	572	0.77	0.84	92	empty
3	376	0.74	0.85	56	empty
4	463	0.66	0.79	50	empty
5	595	0.66	0.76	59	empty

Compared structures

5FKZ · Structure of E.coli Constitutive lysine decarboxylase · the same entry in another collection · chain E against E, TM-score 1.00
P52095 · AlphaFold monomer V2.0 prediction for constitutive lysine decarboxylase (P52095) · a predicted model of the same protein · chain E against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52095
Elsewhere: RCSB PDB 5FKZ · PDBe 5FKZ · UniProt P52095

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