MolNFT v1 · #118943 · protein
Crystal structure of protective ebola virus antibody 114
5FHA · Antibody 114 Fab heavy chain: “Crystal structure of protective ebola virus antibody 114”. X-ray diffraction, 5 pockets (best druggability 0.59). MolNFT v1 #118943 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5FHA
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody 114 Fab heavy chain; Antibody 114 Fab light chain
- Pockets
- 5 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Antibody 114 Fab heavy chain | protein | 215 | 8% helix, 52% strand | — |
| L | Antibody 114 Fab light chain | protein | 212 | 7% helix, 50% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 408 | 0.59 | 0.75 | 41 | empty |
| 2 | 63 | 0.48 | 0.85 | 23 | empty |
| 3 | 122 | 0.40 | 0.75 | 26 | empty |
| 4 | 72 | 0.32 | 0.75 | 19 | empty |
| 5 | 80 | 0.31 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- H–L · 1659 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5FHA · Crystal Structure of Protective Ebola Virus Antibody 114 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5FHA · PDBe 5FHA
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