MolNFT v1 · #11890 · protein
Crystal structure of the focal adhesion targeting domain of focal adhesion kinase
1K05 · Focal adhesion kinase 1: “Crystal structure of the focal adhesion targeting domain of focal adhesion kinase”. X-ray diffraction, 6 pockets (best druggability 0.49). MolNFT v1 #11890 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1K05
- Type
- protein
- Length
- 419 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1
- EC
- 2.7.1.112
- UniProt
- Q05397
- Pockets
- 6 · best druggability 0.49
Structure
x-ray diffraction · 3 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Focal adhesion kinase 1 (EC 2.7.1.112) | protein | 135 | 82% helix, 0% strand | Q05397 |
| B | Focal adhesion kinase 1 (EC 2.7.1.112) | protein | 142 | 81% helix, 0% strand | Q05397 |
| C | Focal adhesion kinase 1 (EC 2.7.1.112) | protein | 142 | 80% helix, 0% strand | Q05397 |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 230 | 0.49 | 0.75 | 29 | empty |
| 2 | 98 | 0.41 | 0.77 | 14 | empty |
| 3 | 75 | 0.40 | 0.79 | 17 | empty |
| 4 | 74 | 0.40 | 0.79 | 17 | empty |
| 5 | 101 | 0.39 | 0.76 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 676 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 659 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1K05 · Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase · the same entry in another collection · chain A against A, TM-score 1.00
- Q05397 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (Q05397) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05397
- Elsewhere: RCSB PDB 1K05 · PDBe 1K05 · UniProt Q05397
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