MolNFT v1 · #118887 · protein

Yellow fever virus helicase

5FFM · Serine protease NS3: “Yellow fever virus helicase”. X-ray diffraction, 2 pockets (best druggability 0.75). MolNFT v1 #118887 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5FFM
Type: protein
Length: 417 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serine protease NS3
EC: 3.4.21.91
UniProt: P03314
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serine protease NS3 (EC 3.4.21.91)	protein	417	32% helix, 19% strand	P03314

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1095	0.75	0.78	85	empty
2	279	0.69	0.84	42	empty

Modifications

Observed in the structure: 13 modified (engineered).

Compared structures

5FFM · Yellow fever virus helicase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03314
Elsewhere: RCSB PDB 5FFM · PDBe 5FFM · UniProt P03314

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