MolNFT v1 · #118764 · protein
Crystal structure of rifampin phosphotransferase rph-lm from listeria monocytogenes in complex with rifampin
5FBT · Phosphoenolpyruvate synthase: “Crystal structure of rifampin phosphotransferase rph-lm from listeria monocytogenes in complex with rifampin”. X-ray diffraction, 2 ligands (5WQ, CL), 7 pockets (best druggability 0.75). MolNFT v1…
- PDB
- 5FBT
- Type
- protein
- Length
- 769 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoenolpyruvate synthase
- Ligands
- 5WQ, CL
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoenolpyruvate synthase | protein | 769 | 47% helix, 13% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 958 | 0.75 | 0.78 | 70 | 5WQ |
| 2 | 347 | 0.59 | 0.77 | 48 | empty |
| 3 | 287 | 0.57 | 0.77 | 40 | empty |
| 4 | 170 | 0.55 | 0.80 | 29 | empty |
| 5 | 149 | 0.52 | 0.80 | 35 | empty |
Modifications
Observed in the structure: 23 modified (engineered).
Compared structures
- 5FBT · Crystal structure of rifampin phosphotransferase RPH-Lm from Listeria monocytogenes in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5FBT · PDBe 5FBT
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