MolNFT v1 · #118613 · protein

Crystal structure of germ-line precursor of 3BNC60 Fab

5F7E · Fab heavy chain: “Crystal structure of germ-line precursor of 3BNC60 Fab”. X-ray diffraction, 3 pockets (best druggability 0.58). MolNFT v1 #118613 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5F7E
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab heavy chain; Fab light chain
Pockets: 3 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Fab heavy chain	protein	221	12% helix, 51% strand	—
L	Fab light chain	protein	207	6% helix, 52% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	456	0.58	0.74	55	empty
2	56	0.44	0.84	22	empty
3	113	0.40	0.76	21	empty

Interfaces

1 interface between chains.

H–L · 1839 Å² buried · 22 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5F7E · Crystal structure of germ-line precursor of 3BNC60 Fab · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5F7E · PDBe 5F7E

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.