MolNFT v1 · #118585 · protein

Crystal structure of tier 2 neutralizing antibody DH428 from a rhesus macaque

5F6I · DH428 antibody heavy chain: “Crystal structure of tier 2 neutralizing antibody DH428 from a rhesus macaque”. X-ray diffraction, 5 pockets (best druggability 0.63). MolNFT v1 #118585 on GenesisL1: 3D structure, binding sites and…

PDB: 5F6I
Type: protein
Length: 420 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DH428 antibody heavy chain; DH428 antibody light chain
Pockets: 5 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	DH428 antibody heavy chain	protein	210	7% helix, 52% strand	—
C	DH428 antibody light chain	protein	210	9% helix, 51% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	648	0.63	0.74	63	empty
2	120	0.43	0.77	28	empty
3	73	0.39	0.79	18	empty
4	52	0.38	0.80	18	empty
5	56	0.34	0.77	15	empty

Interfaces

1 interface between chains.

B–C · 1636 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5F6I · Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5F6I · PDBe 5F6I

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