MolNFT v1 · #118573 · protein
Putative positive transcription regulator (sensor evgs) from shigella flexneri
5F64 · Positive transcription regulator evga: “Putative positive transcription regulator (sensor evgs) from shigella flexneri”. X-ray diffraction, 9 pockets (best druggability 0.82). MolNFT v1 #118573 on GenesisL1: 3D structure, binding…
- PDB
- 5F64
- Type
- protein
- Length
- 816 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Positive transcription regulator evga
- UniProt
- P0ACZ7
- Pockets
- 9 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Positive transcription regulator evga | protein | 204 | 51% helix, 16% strand | P0ACZ7 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 991 | 0.82 | 0.83 | 100 | empty |
| 2 | 269 | 0.75 | 0.88 | 28 | empty |
| 3 | 283 | 0.74 | 0.87 | 34 | empty |
| 4 | 71 | 0.42 | 0.80 | 16 | empty |
| 5 | 64 | 0.40 | 0.80 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–D · 1109 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 1100 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 817 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5F64 · Putative positive transcription regulator (sensor EvgS) from Shigella flexneri · the same entry in another collection · chain D against D, TM-score 1.00
- P0ACZ7 · AlphaFold monomer V2.0 prediction for DNA-binding transcriptional activator evga (P0ACZ7) · a predicted model of the same protein · chain C against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ACZ7
- Elsewhere: RCSB PDB 5F64 · PDBe 5F64 · UniProt P0ACZ7
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