MolNFT v1 · #118563 · protein
Crystal structure of the SNU23-PRP38-MFAP1(217-258) complex of chaetomium thermophilum
5F5U: “Crystal structure of the SNU23-PRP38-MFAP1(217-258) complex of chaetomium thermophilum”. X-ray diffraction, 10 pockets (best druggability 0.73). MolNFT v1 #118563 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5F5U
- Type
- protein
- Length
- 798 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PRP38; Putative uncharacterized protein; Zinc finger domain-containing protein
- UniProt
- G0S1D3, G0SHD7, G0S6R0
- Pockets
- 10 · best druggability 0.73
Structure
x-ray diffraction · 9 distinct chains · 63% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PRP38 | protein | 188 | 56% helix, 11% strand | G0S1D3 |
| B | Putative uncharacterized protein | protein | 45 | 76% helix, 0% strand | G0SHD7 |
| C | Zinc finger domain-containing protein | protein | 32 | 75% helix, 0% strand | G0S6R0 |
| D | PRP38 | protein | 202 | 56% helix, 9% strand | G0S1D3 |
| E | Putative uncharacterized protein | protein | 38 | 95% helix, 0% strand | G0SHD7 |
| F | Zinc finger domain-containing protein | protein | 29 | 76% helix, 0% strand | G0S6R0 |
| G | PRP38 | protein | 194 | 57% helix, 7% strand | G0S1D3 |
| H | Putative uncharacterized protein | protein | 42 | 83% helix, 0% strand | G0SHD7 |
| I | Zinc finger domain-containing protein | protein | 28 | 75% helix, 0% strand | G0S6R0 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 653 | 0.73 | 0.80 | 52 | empty |
| 2 | 386 | 0.64 | 0.79 | 43 | empty |
| 3 | 360 | 0.60 | 0.77 | 37 | empty |
| 4 | 259 | 0.60 | 0.80 | 31 | empty |
| 5 | 263 | 0.59 | 0.79 | 26 | empty |
Interfaces
10 interfaces between chains.
- A–B · 1128 Ų buried · 16 hydrogen bonds · protein-protein
- G–H · 1083 Ų buried · 18 hydrogen bonds · protein-protein
- D–E · 913 Ų buried · 15 hydrogen bonds · protein-protein
- D–F · 755 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 736 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5F5U · Crystal structure of the Snu23-Prp38-MFAP1(217-258) complex of Chaetomium thermophilum · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S1D3
- Every structure of UniProt G0SHD7
- Every structure of UniProt G0S6R0
- Elsewhere: RCSB PDB 5F5U · PDBe 5F5U · UniProt G0S1D3 · UniProt G0SHD7 · UniProt G0S6R0
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