MolNFT v1 · #118533 · protein

Structure of the SD2 domain of human SHROOM2

5F4Y · Protein SHROOM2: “Structure of the SD2 domain of human SHROOM2”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #118533 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5F4Y
Type: protein
Length: 319 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein SHROOM2
UniProt: Q13796
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 93% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein SHROOM2	protein	169	91% helix, 0% strand	Q13796
B	Protein SHROOM2	protein	150	95% helix, 0% strand	Q13796

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	109	0.62	0.87	15	empty
2	122	0.50	0.80	25	empty
3	83	0.42	0.79	14	empty
4	50	0.28	0.75	11	empty

Interfaces

1 interface between chains.

A–B · 896 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5F4Y · Structure of the SD2 domain of Human Shroom2 · the same entry in another collection · chain A against A, TM-score 1.00
Q13796 · AlphaFold monomer V2.0 prediction for protein SHROOM2 (Q13796) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13796
Elsewhere: RCSB PDB 5F4Y · PDBe 5F4Y · UniProt Q13796

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