MolNFT v1 · #118401 · protein
Cohesin subunit PDS5 in complex with SCC1
5F0O · Cohesin subunit PDS5, KLTH0D07062P,KLTH0D07062P…: “Cohesin subunit PDS5 in complex with SCC1”. X-ray diffraction, 9 pockets (best druggability 0.56). MolNFT v1 #118401 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5F0O
- Type
- protein
- Length
- 1,035 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cohesin subunit PDS5, KLTH0D07062P,KLTH0D07062P, KLTH0D07062P,COHESIN subunit PDS5…
- UniProt
- C5DGP8, C5DNF8
- Pockets
- 9 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cohesin subunit PDS5, KLTH0D07062P,KLTH0D07062P, KLTH0D07062P,COHESIN subunit PDS5, KLTH0D07062P,KLTH0D07062P, KLTH0D07062P,COHESIN subunit PDS5, KLTH0D07062P,KLTH0D07062P, KLTH0D07062P,COHESIN subunit PDS5, KLTH0D07062P,KLTH0D07062P | protein | 1018 | 64% helix, 0% strand | C5DGP8 |
| E | KLTH0G16610P | protein | 17 | 0% helix, 6% strand | C5DNF8 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 322 | 0.56 | 0.75 | 45 | empty |
| 2 | 72 | 0.53 | 0.85 | 17 | empty |
| 3 | 154 | 0.51 | 0.79 | 24 | empty |
| 4 | 102 | 0.51 | 0.82 | 17 | empty |
| 5 | 188 | 0.46 | 0.75 | 26 | empty |
Interfaces
1 interface between chains.
- A–E · 1145 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 5F0O · Cohesin subunit Pds5 in complex with Scc1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C5DGP8
- Every structure of UniProt C5DNF8
- Elsewhere: RCSB PDB 5F0O · PDBe 5F0O · UniProt C5DGP8 · UniProt C5DNF8
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