MolNFT v1 · #118338 · protein

Crystal structure of adenylosuccinate lyase from schistosoma mansoni in apo form.

5EYV: “Crystal structure of adenylosuccinate lyase from schistosoma mansoni in apo form.”. X-ray diffraction, 13 pockets (best druggability 0.80). MolNFT v1 #118338 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5EYV
Type: protein
Length: 886 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenylosuccinate lyase
EC: 4.3.2.2
UniProt: G4VQX9
Pockets: 13 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adenylosuccinate lyase (EC 4.3.2.2)	protein	466	68% helix, 4% strand	G4VQX9
B	Adenylosuccinate lyase (EC 4.3.2.2)	protein	420	68% helix, 4% strand	G4VQX9

Pockets

13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	147	0.80	0.96	25	empty
2	75	0.76	0.99	20	empty
3	74	0.76	0.99	20	empty
4	634	0.70	0.78	65	empty
5	249	0.65	0.82	33	empty

Interfaces

1 interface between chains.

A–B · 3543 Å² buried · 62 hydrogen bonds · protein-protein

Compared structures

5EYV · Crystal Structure of Adenylosuccinate lyase from Schistosoma mansoni in APO form. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G4VQX9
Elsewhere: RCSB PDB 5EYV · PDBe 5EYV · UniProt G4VQX9

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