MolNFT v1 · #118328 · protein
Tubulin-binding darpin
5EYL · Designed ankyrin repeat protein (darpin): “Tubulin-binding darpin”. X-ray diffraction, 1 ligand (PO4), 1 pocket (best druggability 0.28). MolNFT v1 #118328 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5EYL
- Type
- protein
- Length
- 273 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Designed ankyrin repeat protein (darpin)
- Ligands
- PO4
- Pockets
- 1 · best druggability 0.28
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Designed ankyrin repeat protein (darpin) | protein | 131 | 53% helix, 0% strand | — |
| B | Designed ankyrin repeat protein (darpin) | protein | 142 | 51% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.28 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 689 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5EYL · Tubulin-binding darpin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5EYL · PDBe 5EYL
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