MolNFT v1 · #118279 · protein + RNA

Crystal structure of brat nhl domain in complex with an 8-nt hunchback mRNA

5EX7 · Brain tumor protein: “Crystal structure of brat nhl domain in complex with an 8-nt hunchback mRNA”. X-ray diffraction, 2 pockets (best druggability 0.71). MolNFT v1 #118279 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5EX7
Type: protein + RNA
Length: 281 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Brain tumor protein; RNA (5'-R(P*UP*UP*UP*GP*UP*UP*GP*U)-3')
UniProt: Q8MQJ9
Pockets: 2 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 1% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Brain tumor protein	protein	274	1% helix, 52% strand	Q8MQJ9
B	RNA (5'-R(PUPUPUPGPUPUPGPU)-3')	rna	7	—	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	395	0.71	0.82	38	empty
2	133	0.68	0.90	25	empty

Interfaces

1 interface between chains.

A–B · 845 Å² buried · 29 hydrogen bonds · protein-nucleic

Compared structures

5EX7 · Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA · the same entry in another collection · chain A against A, TM-score 1.00
Q8MQJ9 · AlphaFold monomer V2.0 prediction for brain tumor protein (Q8MQJ9) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8MQJ9
Elsewhere: RCSB PDB 5EX7 · PDBe 5EX7 · UniProt Q8MQJ9

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