MolNFT v1 · #11821 · protein
Human acidic fibroblast growth factor. 141 amino acid form with amino terminal his tag and cys 117 replaced with val (C117V).
1JY0: “Human acidic fibroblast growth factor. 141 amino acid form with amino terminal his tag and cys 117 replaced…”. X-ray diffraction, 2 pockets (best druggability 0.36). MolNFT v1 #11821 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1JY0
- Type
- protein
- Length
- 281 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acidic fibroblast growth factor
- UniProt
- P05230
- Pockets
- 2 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acidic fibroblast growth factor | protein | 140 | 6% helix, 38% strand | P05230 |
| B | Acidic fibroblast growth factor | protein | 141 | 6% helix, 38% strand | P05230 |
Ligands and binding sites
- FMT · Formic acid · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.36 | 0.79 | 18 | empty |
| 2 | 104 | 0.36 | 0.74 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 443 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1JY0 · Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag… · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 1JY0 · PDBe 1JY0 · UniProt P05230
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