MolNFT v1 · #118206 · protein

Rat prestin stas domain in complex with nitrate

5EUW · PRESTIN,PRESTIN: “Rat prestin stas domain in complex with nitrate”. X-ray diffraction, 1 ligand (NO3), 3 pockets (best druggability 0.61). MolNFT v1 #118206 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5EUW
Type: protein
Length: 129 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PRESTIN,PRESTIN
UniProt: Q9EPH0
Ligands: NO3
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	PRESTIN,PRESTIN	protein	129	35% helix, 22% strand	Q9EPH0

Ligands and binding sites

NO3 · Nitrate ion · ion · chains A
EDO · 1,2-ethanediol · additive · 3 copies · chains A
PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A
PG4 · Tetraethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.61	0.89	14	empty
2	57	0.39	0.80	15	NO3
3	75	0.30	0.73	17	PG4

Compared structures

5EUW · Rat prestin STAS domain in complex with nitrate · the same entry in another collection · chain A against A, TM-score 1.00
Q9EPH0 · AlphaFold monomer V2.0 prediction for prestin (Q9EPH0) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9EPH0
Elsewhere: RCSB PDB 5EUW · PDBe 5EUW · UniProt Q9EPH0

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