MolNFT v1 · #1182 · protein

Uncleaved alpha-1-antitrypsin

1ATU: “Uncleaved alpha-1-antitrypsin”. X-ray diffraction, 8 pockets (best druggability 0.76). MolNFT v1 #1182 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ATU
Type: protein
Length: 374 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-1-antitrypsin
UniProt: P01009
Pockets: 8 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 18% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-1-antitrypsin	protein	374	18% helix, 13% strand	P01009

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	81	0.76	0.98	25	empty
2	369	0.66	0.80	44	empty
3	77	0.55	0.86	18	empty
4	96	0.50	0.82	27	empty
5	102	0.46	0.80	22	empty

Compared structures

1ATU · Uncleaved alpha-1-antitrypsin · the same entry in another collection · chain A against A, TM-score 1.00
P01009 · AlphaFold monomer V2.0 prediction for alpha-1-antitrypsin (P01009) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01009
Elsewhere: RCSB PDB 1ATU · PDBe 1ATU · UniProt P01009

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