MolNFT v1 · #118187 · protein
The role of the C-terminal region on the oligomeric state and enzymatic activity of trypanosoma cruzi hypoxanthine phosphoribosyl transferase
5EUC · Hypoxanthine-guanine phosphoribosyltransferase: “The role of the C-terminal region on the oligomeric state and enzymatic activity of trypanosoma cruzi…”. X-ray diffraction, 10 pockets (best druggability 0.74). MolNFT v1 #118187 on…
- PDB
- 5EUC
- Type
- protein
- Length
- 774 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypoxanthine-guanine phosphoribosyltransferase
- UniProt
- Q4DRC4
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 29% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypoxanthine-guanine phosphoribosyltransferase | protein | 197 | 30% helix, 31% strand | Q4DRC4 |
| B | Hypoxanthine-guanine phosphoribosyltransferase | protein | 195 | 29% helix, 32% strand | Q4DRC4 |
| C | Hypoxanthine-guanine phosphoribosyltransferase | protein | 193 | 30% helix, 32% strand | Q4DRC4 |
| D | Hypoxanthine-guanine phosphoribosyltransferase | protein | 189 | 28% helix, 32% strand | Q4DRC4 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1084 | 0.74 | 0.77 | 96 | empty |
| 2 | 610 | 0.67 | 0.76 | 66 | empty |
| 3 | 461 | 0.64 | 0.77 | 45 | empty |
| 4 | 158 | 0.55 | 0.81 | 22 | empty |
| 5 | 148 | 0.53 | 0.81 | 23 | empty |
Interfaces
6 interfaces between chains.
- A–C · 1774 Ų buried · 25 hydrogen bonds · protein-protein
- B–D · 1741 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 1074 Ų buried · 33 hydrogen bonds · protein-protein
- A–D · 1060 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 105 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5EUC · The role of the C-terminal region on the oligomeric state and enzymatic activity of… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4DRC4
- Elsewhere: RCSB PDB 5EUC · PDBe 5EUC · UniProt Q4DRC4
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