MolNFT v1 · #118116 · protein

Crystal structure of group a streptococcus hupz

5ESC: “Crystal structure of group a streptococcus hupz”. X-ray diffraction, 11 pockets (best druggability 0.64). MolNFT v1 #118116 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5ESC
Type: protein
Length: 476 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hupz
UniProt: Q1JHG0
Pockets: 11 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Hupz	protein	119	24% helix, 45% strand	Q1JHG0

Pockets

11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.64	0.88	18	empty
2	104	0.61	0.87	14	empty
3	273	0.54	0.76	29	empty
4	235	0.54	0.77	29	empty
5	228	0.54	0.77	29	empty

Interfaces

5 interfaces between chains.

C–D · 1093 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 1081 Å² buried · 11 hydrogen bonds · protein-protein
A–C · 567 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 79 Å² buried · 1 hydrogen bond · protein-protein
B–C · 78 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5ESC · Crystal structure of Group A Streptococcus HupZ · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q1JHG0
Elsewhere: RCSB PDB 5ESC · PDBe 5ESC · UniProt Q1JHG0

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.