MolNFT v1 · #118114 · protein
Crystal structure of anti-HCV E2 antibody HC84-26
5ESA · Anti-HCV E2 glycoprotein Fab heavy chain: “Crystal structure of anti-HCV E2 antibody HC84-26”. X-ray diffraction, 4 pockets (best druggability 0.66). MolNFT v1 #118114 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ESA
- Type
- protein
- Length
- 425 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-HCV E2 glycoprotein Fab heavy chain; Anti-HCV E2 glycoprotein Fab light chain
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anti-HCV E2 glycoprotein Fab heavy chain | protein | 213 | 4% helix, 53% strand | — |
| B | Anti-HCV E2 glycoprotein Fab light chain | protein | 212 | 7% helix, 51% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 708 | 0.66 | 0.75 | 63 | empty |
| 2 | 100 | 0.34 | 0.73 | 20 | empty |
| 3 | 68 | 0.29 | 0.73 | 19 | empty |
| 4 | 51 | 0.29 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1849 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5ESA · Crystal structure of anti-HCV E2 antibody HC84-26 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5ESA · PDBe 5ESA
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