MolNFT v1 · #118093 · protein
Crystal structure of elongation domain of phomopsis amygdali fusicoccadiene synthase
5ERN: “Crystal structure of elongation domain of phomopsis amygdali fusicoccadiene synthase”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #118093 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ERN
- Type
- protein
- Length
- 573 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusicoccadiene synthase
- EC
- 2.5.1.29
- UniProt
- A2PZA5
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusicoccadiene synthase (EC 2.5.1.29) | protein | 286 | 74% helix, 0% strand | A2PZA5 |
| B | Fusicoccadiene synthase (EC 2.5.1.29) | protein | 287 | 76% helix, 0% strand | A2PZA5 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1044 | 0.78 | 0.80 | 87 | empty |
| 2 | 907 | 0.78 | 0.80 | 79 | empty |
| 3 | 79 | 0.49 | 0.83 | 18 | empty |
| 4 | 68 | 0.34 | 0.76 | 14 | empty |
| 5 | 58 | 0.29 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1946 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 5ERN · Crystal structure of elongation domain of Phomopsis amygdali fusicoccadiene synthase · the same entry in another collection · chain A against A, TM-score 1.00
- A2PZA5 · AlphaFold monomer V2.0 prediction for fusicoccadiene synthase (A2PZA5) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A2PZA5
- Elsewhere: RCSB PDB 5ERN · PDBe 5ERN · UniProt A2PZA5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.