MolNFT v1 · #117892 · protein + RNA
Structure of the QUA1-kh domain of T-star in complex with uaau RNA
5ELT · Kh domain-containing, RNA-binding, signal transduction…: “Structure of the QUA1-kh domain of T-star in complex with uaau RNA”. X-ray diffraction, 2 pockets (best druggability 0.38). MolNFT v1 #117892 on GenesisL1: 3D structure…
- PDB
- 5ELT
- Type
- protein + RNA
- Length
- 306 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kh domain-containing, RNA-binding, signal transduction- associated protein 3; RNA…
- UniProt
- O75525
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 3 distinct chains · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Kh domain-containing, RNA-binding, signal transduction- associated protein 3 | protein | 152 | 50% helix, 15% strand | O75525 |
| A | Kh domain-containing, RNA-binding, signal transduction- associated protein 3 | protein | 146 | 53% helix, 16% strand | O75525 |
| E, F | RNA (5'-R(P*UP*AP*AP*U)-3') | rna | 4 | — | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.38 | 0.75 | 21 | empty |
| 2 | 83 | 0.34 | 0.75 | 19 | empty |
Interfaces
3 interfaces between chains.
- B–A · 2269 Ų buried · 32 hydrogen bonds · protein-protein
- A–F · 599 Ų buried · 12 hydrogen bonds · protein-nucleic
- B–E · 569 Ų buried · 13 hydrogen bonds · protein-nucleic
Compared structures
- 5ELT · Structure of the QUA1-KH domain of T-STAR in complex with UAAU RNA · the same entry in another collection · chain B against B, TM-score 1.00
- O75525 · AlphaFold monomer V2.0 prediction for kh domain-containing, RNA- binding, signal… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75525
- Elsewhere: RCSB PDB 5ELT · PDBe 5ELT · UniProt O75525
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