MolNFT v1 · #11786 · protein

Chalcone synthase--F215S mutant

1JWX · Chalcone synthase 2: “Chalcone synthase--F215S mutant”. X-ray diffraction, 1 pocket (best druggability 0.74). MolNFT v1 #11786 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1JWX
Type: protein
Length: 388 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chalcone synthase 2
EC: 2.3.1.74
UniProt: P30074
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chalcone synthase 2 (EC 2.3.1.74)	protein	388	43% helix, 23% strand	P30074

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	391	0.74	0.84	48	empty

Modifications

Observed in the structure: 1 modified (oxidation).

Compared structures

1JWX · Chalcone Synthase--F215S mutant · the same entry in another collection · chain A against A, TM-score 1.00
P30074 · AlphaFold monomer V2.0 prediction for chalcone synthase 2 (P30074) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30074
Elsewhere: RCSB PDB 1JWX · PDBe 1JWX · UniProt P30074

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