MolNFT v1 · #117825 · protein

Structure of dictyostelium discoideum myosin VII MYTH4-ferm MF2 domain, mutant 1

5EJS · Myosin-I heavy chain: “Structure of dictyostelium discoideum myosin VII MYTH4-ferm MF2 domain, mutant 1”. X-ray diffraction, 11 pockets (best druggability 0.73). MolNFT v1 #117825 on GenesisL1: 3D structure, binding sites and…

PDB: 5EJS
Type: protein
Length: 981 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin-I heavy chain
UniProt: Q9U1M8
Pockets: 11 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myosin-I heavy chain	protein	496	49% helix, 14% strand	Q9U1M8
B	Myosin-I heavy chain	protein	485	49% helix, 14% strand	Q9U1M8

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	593	0.73	0.80	59	empty
2	585	0.72	0.80	62	empty
3	541	0.66	0.77	74	empty
4	408	0.61	0.76	53	empty
5	60	0.50	0.86	21	empty

Interfaces

1 interface between chains.

A–B · 601 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

5EJS · Structure of Dictyostelium Discoideum Myosin VII MyTH4-FERM MF2 domain, mutant 1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9U1M8 · AlphaFold monomer V2.0 prediction for myosin-I heavy chain (Q9U1M8) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9U1M8
Elsewhere: RCSB PDB 5EJS · PDBe 5EJS · UniProt Q9U1M8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.