MolNFT v1 · #117726 · protein
2.70 a crystal structure of the amb a 11 cysteine protease, a major ragweed pollen allergen, in its proform
5EGW: “2.70 a crystal structure of the amb a 11 cysteine protease, a major ragweed pollen allergen, in its proform”. X-ray diffraction, 5 pockets (best druggability 0.78). MolNFT v1 #117726 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5EGW
- Type
- protein
- Length
- 688 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine protease
- UniProt
- V5LU01
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine protease | protein | 363 | 30% helix, 15% strand | V5LU01 |
| B | Cysteine protease | protein | 325 | 34% helix, 16% strand | V5LU01 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 286 | 0.78 | 0.90 | 48 | empty |
| 2 | 163 | 0.68 | 0.88 | 41 | empty |
| 3 | 257 | 0.66 | 0.83 | 37 | empty |
| 4 | 232 | 0.56 | 0.78 | 38 | empty |
| 5 | 64 | 0.27 | 0.72 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1590 Ų buried · 29 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5EGW · 2.70 A crystal structure of the Amb a 11 cysteine protease, a major ragweed pollen… · the same entry in another collection · chain A against A, TM-score 1.00
- V5LU01 · AlphaFold monomer V2.0 prediction for cysteine protease amb a 11.0101 (V5LU01) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt V5LU01
- Elsewhere: RCSB PDB 5EGW · PDBe 5EGW · UniProt V5LU01
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