MolNFT v1 · #117704 · protein
The cap binding site of influenza virus protein PB2 as a drug target
5EG9 · Polymerase basic protein 2: “The cap binding site of influenza virus protein PB2 as a drug target”. X-ray diffraction, 4 pockets (best druggability 0.58). MolNFT v1 #117704 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5EG9
- Type
- protein
- Length
- 313 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase basic protein 2
- UniProt
- Q6DNL8
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase basic protein 2 | protein | 157 | 24% helix, 41% strand | Q6DNL8 |
| B | Polymerase basic protein 2 | protein | 156 | 24% helix, 41% strand | Q6DNL8 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 251 | 0.58 | 0.79 | 28 | empty |
| 2 | 188 | 0.49 | 0.77 | 27 | empty |
| 3 | 117 | 0.44 | 0.77 | 21 | empty |
| 4 | 77 | 0.40 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 380 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5EG9 · The cap binding site of influenza virus protein PB2 as a drug target · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6DNL8
- Elsewhere: RCSB PDB 5EG9 · PDBe 5EG9 · UniProt Q6DNL8
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